Difference in intestinal microbiota between breast-fed and formula-fed children

Razlika u crijevnoj mikrobioti između djece hranjene majčinim mlijekom i djece hranjene adaptiranim mlijekom

Authors

  • Sara Bezak KBC Rijeka

Keywords:

intestinal microbiota, dietary habits, immune system, breastfeeding, adapted milk formulas

Abstract

Intestinal (gut) microbiota is a community of microorganisms that colonize human digestive system. In recent times, intestinal microbiota has been intensively researched, that is, its role in the host's health has been a research subject. In the human body, among other things, the intestinal microbiota plays the role of a central regulator of metabolism and immune function, and disturbances in the balance of the intestinal microbiota are associated today with numerous pathological conditions. The composition and diversity of the intestinal microbiota are influenced by numerous factors, among which the dietary habits of the individual are cited as the most significant, therefore the question arises to what extent dietary habits can influence the diversity and composition of the intestinal microbiota and to what extent changes in the intestinal microbiota conditioned by dietary habits can influence on the host's health. The intestinal microbiota develops from an early age, and some authors suggest that the formation of the intestinal microbiota begins already in utero, therefore in this paper we will briefly try to present recent findings on the topic of the influence of diet on the intestinal microbiota of infants, that is, point out the differences in the intestinal microbiota of breastfed children and children fed with adapted milk formula.

References

BIBLIOGRAPHY

Derrien M, Alvarez AS, de Vos WM. The Gut Microbiota in the First Decade of Life. Trends Microbiol [Internet]. 2019;27(12):997–1010. Available from: https://doi.org/10.1016/j.tim.2019.08.001

Schoeler M, Caesar R. Dietary lipids, gut microbiota and lipid metabolism. Rev Endocr Metab Disord. 2019;20(4):461–72.

Korpela K, de Vos WM. Infant gut microbiota restoration: state of the art. Gut Microbes [Internet]. 2022;14(1):1–14. Available from: https://doi.org/10.1080/19490976.2022.2118811

Grech A, Collins CE, Holmes A, Lal R, Duncanson K, Taylor R, et al. Maternal exposures and the infant gut microbiome: a systematic review with meta-analysis. Gut Microbes [Internet]. 2021;13(1):1–30. Available from: https://doi.org/10.1080/19490976.2021.1897210

Kim H, Sitarik AR, Woodcroft K, Johnson CC, Zoratti E. Birth Mode, Breastfeeding, Pet Exposure, and Antibiotic Use: Associations With the Gut Microbiome and Sensitization in Children. Curr Allergy Asthma Rep. 2019;19(4):17–9.

Beller L, Deboutte W, Falony G, Vieira-Silva S, Tito RY, Valles-Colomer M, et al. Successional Stages in Infant Gut Microbiota Maturation. MBio. 2021;12(6):1–13.

Tanaka M, Nakayama J. Development of the gut microbiota in infancy and its impact on health in later life. Allergol Int [Internet]. 2017;66(4):515–22. Available from: https://doi.org/10.1016/j.alit.2017.07.010

Navarro‐Tapia E, Sebastiani G, Sailer S, Toledano LA, Serra‐delgado M, García-Algar Ó, et al. Probiotic supplementation during the perinatal and infant period: Effects on gut dysbiosis and disease. Nutrients. 2020;12(8):1–42.

Moore RE, Townsend SD. Temporal development of the infant gut microbiome. Open Biol. 2019;9(9).

Tun HM, Konya T, Takaro TK, Brook JR, Chari R, Field CJ, et al. Exposure to household furry pets influences the gut microbiota of infants at 3-4 months following various birth scenarios. Microbiome. 2017;5(1):1–14.

Zhang S, Li T, Xie J, Zhang D, Pi C, Zhou L, et al. Gold standard for nutrition: a review of human milk oligosaccharide and its effects on infant gut microbiota. Microb Cell Fact [Internet]. 2021;20(1):1–16. Available from: https://doi.org/10.1186/s12934-021-01599-y

Laursen MF, Sakanaka M, von Burg N, Mörbe U, Andersen D, Moll JM, et al. Bifidobacterium species associated with breastfeeding produce aromatic lactic acids in the infant gut. Nat Microbiol. 2021;6(11):1367–82.

Sakanaka M, Gotoh A, Yoshida K, Odamaki T, Koguchi H, Xiao JZ, et al. Varied pathways of infant gut-associated Bifidobacterium to assimilate human milk oligosaccharides: Prevalence of the gene set and its correlation with bifidobacteria-rich microbiota formation. Nutrients. 2020;12(1):1–21.

Henrick BM, Rodriguez L, Lakshmikanth T, Pou C, Henckel E, Arzoomand A, et al. Bifidobacteria-mediated immune system imprinting early in life. Cell [Internet]. 2021;184(15):3884-3898.e11. Available from: https://doi.org/10.1016/j.cell.2021.05.030

Le Doare K, Holder B, Bassett A, Pannaraj PS. Mother’s Milk: A purposeful contribution to the development of the infant microbiota and immunity. Front Immunol. 2018;9(FEB).

Wicinski M, Sawicka E, Gebalski J, Kubiak K, Malinowski B. Human Milk Oligosaccharides : Health Benefits , and Pharmacology. Nutrients. 2020;12(266):1–14.

Lyons KE, Ryan CA, Dempsey EM, Ross RP, Stanton C. Breast milk, a source of beneficial microbes and asLyons, K. E., Ryan, C. A., Dempsey, E. M., Ross, R. P., & Stanton, C. (2020). Breast milk, a source of beneficial microbes and associated benefits for infant health. Nutrients, 12(4), 1–30. https://doi.or. Nutrients. 2020;12(4):1–30.

Natividad JM, Marsaux B, Rodenas CLG, Rytz A, Vandevijver G, Marzorati M, et al. Human Milk Oligosaccharides and Lactose Differentially Affect Infant Gut Microbiota and Intestinal Barrier In Vitro. Nutrients. 2022;14(12).

Smilowitz JT, O’Sullivan A, Barile D, German JB, Lönnerdal B, Slupsky CM. The human milk metabolome reveals diverse oligosaccharide profiles. J Nutr. 2013;143(11):1709–18.

Yi DY, Kim SY. Human breast milk composition and function in human health: From nutritional components to microbiome and micrornas. Nutrients. 2021;13(9).

Fitzstevens JL, Smith KC, Hagadorn JI, Caimano MJ, Matson AP, Brownell EA. Systematic Review of the Human Milk Microbiota. Nutr Clin Pract Off Publ Am Soc Parenter Enter Nutr. 2017 Jun;32(3):354–64.

Huang T, Zeng Z, Liang X, Tang X, Luo H, Wang D, et al. Effect of breast milk with or without bacteria on infant gut microbiota. BMC Pregnancy Childbirth [Internet]. 2022;22(1):1–11. Available from: https://doi.org/10.1186/s12884-022-04930-6

Milani C, Mancabelli L, Lugli GA, Duranti S, Turroni F, Ferrario C, et al. Exploring vertical transmission of bifidobacteria from mother to child. Appl Environ Microbiol. 2015;81(20):7078–87.

Asnicar F, Manara S, Zolfo M, Truong DT, Scholz M, Armanini F, et al. crossm Studying Vertical Microbiome Transmission from Mothers to Infants by. mSystems. 2017;2(1):1–13.

Carr LE, Virmani MD, Rosa F, Munblit D, Matazel KS, Elolimy AA, et al. Role of Human Milk Bioactives on Infants’ Gut and Immune Health. Front Immunol. 2021;12(February):1–17.

Gopalakrishna KP, Hand TW. Influence of maternal milk on the neonatal intestinal microbiome. Nutrients. 2020;12(3).

Stewart CJ, Ajami NJ, O’Brien JL, Hutchinson DS, Smith DP, Wong MC, et al. Temporal development of the gut microbiome in early childhood from the TEDDY study. Nature [Internet]. 2018;562(7728):583–8. Available from: http://dx.doi.org/10.1038/s41586-018-0617-x

Bridge G. Consider the Whole Picture When Discussing Infant Formula and Breast Milk. J Nutr [Internet]. 2021;151(6):1375–7. Available from: https://doi.org/10.1093/jn/nxab132

Kong KL, Burgess B, Morris KS, Re T, Hull HR, Sullivan DK, et al. Association between Added Sugars from Infant Formulas and Rapid Weight Gain in US Infants and Toddlers. J Nutr. 2021;151(6):1572–80.

Ratsika A, Codagnone MC, O’Mahony S, Stanton C, Cryan JF. Priming for Life: Early Life Nutrition and the Microbiota-Gut-Brain Axis. Nutrients. 2021;13(423):1–33.

Salminen S, Stahl B, Vinderola G, Szajewska H. Infant formula supplemented with biotics: Current knowledge and future perspectives. Nutrients. 2020;12(7):1–20.

Fabiano V, Indrio F, Verduci E, Calcaterra V, Pop TL, Mari A, et al. Term infant formulas influencing gut microbiota: An overview. Nutrients. 2021;13(12):1–26.

Neumer F, Urraca O, Alonso J, Palencia J, Varea V, Theis S, et al. Long‐term safety and efficacy of prebiotic enriched infant formula—a randomized controlled trial. Nutrients. 2021;13(4):1–16.

Estorninos E, Lawenko RB, Palestroque E, Sprenger N, Benyacoub J, Kortman GAM, et al. Term infant formula supplemented with milk-derived oligosaccharides shifts the gut microbiota closer to that of human milk-fed infants and improves intestinal immune defense: a randomized controlled trial. Am J Clin Nutr. 2022;115(1):142–53.

Cukrowska B, Bierła JB, Zakrzewska M, Klukowski M, Maciorkowska E. The relationship between the infant gut microbiota and allergy. The role of Bifidobacterium breve and prebiotic oligosaccharides in the activation of anti-allergic mechanisms in early life. Nutrients. 2020;12(4).

Cheung KY, Petrou L, Helfer B, Porubayeva E, Dolgikh E, Ali S, et al. Health and nutrition claims for infant formula: international cross sectional survey. BMJ [Internet]. 2023;380. Available from: http://www.ncbi.nlm.nih.gov/pubmed/36792145%0Ahttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9930154

Mennella JA, Li Y, Bittinger K, Friedman ES, Zhao C, Li H, et al. The Macronutrient Composition of Infant Formula Produces Differences in Gut Microbiota Maturation That Associates with Weight Gain Velocity and Weight Status. Nutrients. 2022;14(6).

Pärnänen KMM, Hultman J, Markkanen M, Satokari R, Rautava S, Lamendella R, et al. Early-life formula feeding is associated with infant gut microbiota alterations and an increased antibiotic resistance load. Am J Clin Nutr. 2022;115(2):407–21.

Jones RB, Berger PK, Plows JF, Alderete TL, Millstein J, Fogel J, et al. Lactose-reduced infant formula with added corn syrup solids is associated with a distinct gut microbiota in Hispanic infants. Gut Microbes [Internet]. 2020;12(1):1–14. Available from: https://doi.org/10.1080/19490976.2020.1813534

Chua MC, Ben-Amor K, Lay C, Neo AGE, Chiang WC, Rao R, et al. Effect of Synbiotic on the Gut Microbiota of Cesarean Delivered Infants: A Randomized, Double-blind, Multicenter Study. J Pediatr Gastroenterol Nutr. 2017;65(1):102–6.

Kosuwon P, Lao-Araya M, Uthaisangsook S, Lay C, Bindels J, Knol J, et al. A synbiotic mixture of scGOS/lcFOS and Bifidobacterium breve M-16V increases faecal Bifidobacterium in healthy young children. Benef Microbes. 2018 Jun;9(4):541–52.

Béghin L, Tims S, Roelofs M, Rougé C, Oozeer R, Rakza T, et al. Fermented infant formula (with Bifidobacterium breve C50 and Streptococcus thermophilus O65) with prebiotic oligosaccharides is safe and modulates the gut microbiota towards a microbiota closer to that of breastfed infants. Clin Nutr. 2021;40(3):778–87.

Published

2024-12-23

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