Podocytes and the actin cytoskeleton as a feasible therapeutic target

Authors

  • Sanja Sever Harvard Medical School and Massachusetts General Hospital, Charlestown, MA
  • Changkyo Gu Harvard Medical School and Massachusetts General Hospital, Charlestown, MA

DOI:

https://doi.org/10.18054/pb.v118i4.4576

Abstract

Podocyte injury is a hallmark of the glomerular disease, which is a direct cause of chronic kidney diseases. Importantly, podocyte injury is a consequence of the dysregulation of the actin cytoskeleton. In diverse animal models of proteinuric glomerular disease, recovering the integrity of the actin structure in podocytes resulted in beneficial effects. In this review, we focus on the premise of targeting the actin cytoskeleton as a feasible therapeutics for treating chronic kidney diseases

Author Biography

  • Sanja Sever, Harvard Medical School and Massachusetts General Hospital, Charlestown, MA

    Associate Professor in Medicine

     

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Published

2017-03-17

Issue

Vol. 118 No. 4 (2016)

Section

Articles

License

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